Low-Dimensional Compounds Containing Bioactive Ligands. Part XX: Crystal Structures, Cytotoxic, Antimicrobial Activities and DNA/BSA Binding of Oligonuclear Zinc Complexes with Halogen Derivatives of 8-Hydroxyquinoline

Two tetranuclear [Zn4Cl2(ClQ)6]·2DMF (1) and [Zn4Cl2(ClQ)6(H2O)2]·4DMF (2), as well three dinuclear [Zn2(ClQ)3(HClQ)3]I3 (3), [Zn2(dClQ)2(H2O)6(SO4)] (4) [Zn2(dBrQ)2(H2O)6(SO4)] (5), complexes (HClQ = 5-chloro-8-hydroxyquinoline, HdClQ 5,7-dichloro-8-hydroxyquinoline HdBrQ 5,7-dibromo-8-hydroxyquinoline) were prepared possible anticancer or antimicrobial agents characterized by IR spectroscopy, elemental analysis single crystal X-ray structure analysis. The stability of the in solution was verified NMR spectroscopy. Antiproliferative activity selectivity studied using vitro MTT assay against HeLa, A549, MCF-7, MDA-MB-231, HCT116 Caco-2 cancer cell lines on Cos-7 non-cancerous line. most sensitive to tested Among complexes, complex 3 showed highest cytotoxicity all lines. Unfortunately, only poor normal cells, except for 5, which a certain level selectivity. Antibacterial potential observed 5 only. Moreover, DNA/BSA binding 1–3 investigated UV-vis fluorescence spectroscopic methods.